| 1998 | - | founded by Daniel A. Hilbrich, D.O.
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| 1999 | - | became affiliated with the Michigan State University College of Osteopathic Medicine (MSUCOM) dermatology residency program, Pontiac Osteopathic Hospital site
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| 2000 | - | became affiliated with the MSUCOM dermatology residency program, Henry Ford BiCounty Hospital site (currently Oakwood Southshore Medical Center site)
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| 2001 | - | expanded laboratory size to accommodate growth
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| 2003 | - | John C. Pui, M.D., of New York University joins HDL
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| 2004 | - | became affiliated with the Henry Ford Hospital dermatology residency program
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| 2006 | - | became affiliated with the MSUCOM dermatology residency program, Botsford Hospital site
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| 2006 | - | partnered with Aurora Diagnostics, with Dr. Pui designated as Laboratory Director
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| 2007 | - | Christopher J. Schwimer, D.O., of William Beaumont Hospital joins HDL
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| 2008 | - | expanded laboratory size to accommodate growth
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